Description

(E)-Methyl 4-(1H-Indol-3-Yl)-4-Oxobut-2-Enoate is a high-purity, synthetic organic compound featuring a conjugated enone system linked to an indole moiety. This specific molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex bioactive molecules, including potential kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Serves as a crucial building block for constructing compound libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Agrochemical Development: Used in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological processes and identify new therapeutic targets.
• Organic Synthesis: A versatile Michael acceptor and electrophile for constructing complex heterocyclic systems and natural product analogs.

Basic Information

Product Name	(E)-Methyl 4-(1H-Indol-3-Yl)-4-Oxobut-2-Enoate
CAS No.	59000-14-5
Molecular Formula	C₁₃H₁₁NO₃
Molecular Weight	229.23 g/mol
Synonyms	Methyl (2E)-4-(1H-indol-3-yl)-4-oxo-2-butenoate; (E)-Methyl 4-(indol-3-yl)-4-oxobut-2-enoate; 3-Indolyl 4-methoxy-4-oxo-2-butenoate; Methyl 4-(3-indolyl)-4-oxo-2-butenoate; 2-Butenoic acid, 4-(1H-indol-3-yl)-4-oxo-, methyl ester, (2E)-; 59000-14-5; (E)-Methyl 4-(1H-indol-3-yl)-4-oxobut-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-Methyl 4-(1H-Indol-3-Yl)-4-Oxobut-2-Enoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and reliable documentation supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.