Description

Rac trans-10,11-Dihydro-10,11-Dihydroxy Carbamazepine is a key dihydrodiol metabolite and synthetic intermediate of the anticonvulsant drug carbamazepine. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel derivatives. It serves as a critical reference standard and building block for analytical laboratories, academic institutions, and pharmaceutical companies engaged in neuroscience and CNS drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of carbamazepine metabolites in bioanalytical studies, clinical research, and therapeutic drug monitoring (TDM).
• Metabolic Pathway Research: Essential for investigating the metabolic fate, enzymatic pathways, and potential toxicology of carbamazepine in preclinical and clinical settings.
• Chemical Synthesis Intermediate: Acts as a versatile precursor in the organic synthesis of novel carbamazepine analogs and other complex molecules for pharmacological evaluation.
• Analytical Method Development: Employed in the development, validation, and calibration of analytical methods such as HPLC, LC-MS/MS, and GC-MS for accurate metabolite profiling.
• Impurity Standard: Used to identify, qualify, and control related substances and degradation products in carbamazepine active pharmaceutical ingredient (API) and finished dosage forms, supporting regulatory filings.

Basic Information

Product Name	Rac trans-10,11-Dihydro-10,11-Dihydroxy Carbamazepine
CAS No.	58955-93-4
Molecular Formula	C15H14N2O3
Molecular Weight	270.28 g/mol
Synonyms	10,11-Dihydro-10,11-trans-dihydroxycarbamazepine; trans-10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide; Carbamazepine-10,11-trans-dihydrodiol; CBZ-dihydrodiol; trans-Carbamazepine dihydrodiol; 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10,11-dihydroxy-, (10R,11R)-rel-; (rel-10R,11R)-10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide
EINECS	Contact for details

Quality Control

Our Rac trans-10,11-Dihydro-10,11-Dihydroxy Carbamazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with relevant pharmacopeial guidelines and can supply material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.