Description

Bis(2-Chloroethyl)Amine-D4 Hydrochloride is a deuterated derivative of a key nitrogen mustard alkylating agent, offering a stable isotopic label for advanced research and analytical applications. This compound is critical for mechanistic studies, metabolic pathway tracing, and as an internal standard in quantitative mass spectrometry, providing unparalleled precision in pharmacokinetic and toxicological research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology drug development and biochemical analysis.

Application

• As a stable isotopic internal standard (SIS) for the accurate quantification of nitrogen mustard analogs and their metabolites via LC-MS/MS.
• In deuterium-labeling studies to investigate the metabolic fate, biotransformation pathways, and pharmacokinetics of alkylating agents.
• For mechanistic biochemical research, enabling detailed studies of DNA alkylation and repair processes without interference from endogenous compounds.
• Use in the synthesis of deuterated reference materials and metabolites for regulatory bioanalysis and drug development.
• Application in environmental and forensic analysis as a tracer for detecting and studying related chemical warfare agent degradation products.

Basic Information

Product Name	Bis(2-Chloroethyl)Amine-D4 Hydrochloride
CAS No.	58880-33-4
Molecular Formula	C4H4D4Cl2N•HCl
Molecular Weight	204.95 g/mol
Synonyms	2-Chloro-N-(2-chloroethyl)ethanamine-d4 Hydrochloride; HN2-d4 Hydrochloride; Mechlorethamine-d4 Hydrochloride; Nitrogen Mustard-d4 Hydrochloride; Dichloro(2-chloroethyl)amine-d4 Hydrochloride; Bis(β-chloroethyl)amine-d4 Hydrochloride; Chlormethine-d4 Hydrochloride; MBA-d4 Hydrochloride
EINECS	Contact for details

Quality Control

Our Bis(2-Chloroethyl)Amine-D4 Hydrochloride is produced under stringent conditions to ensure high isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity, and impurity profiles. We adhere to cGMP principles for research chemicals, and our quality system is designed to meet the exacting standards of pharmaceutical and analytical laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.