Description

5-Bromo-1-(Piperidin-4-Yl)-1H-Benzo[D]Imidazol-2(3H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the benzimidazole chemical class. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting various therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: The benzimidazole core is a privileged scaffold in the design of protease inhibitors for antiviral and other therapeutic applications.
• Kinase Inhibitor Synthesis: Serves as a precursor in the development of small molecule kinase inhibitors, a major class in oncology drug discovery.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and biological pathways in academic and industrial research.
• Custom Synthesis & Scale-Up: A starting material for custom synthesis projects, supporting process development from milligram to kilogram scale for clinical trials.

Basic Information

Product Name	5-Bromo-1-(Piperidin-4-Yl)-1H-Benzo[D]Imidazol-2(3H)-One
CAS No.	58878-84-5
Molecular Formula	C₁₂H₁₄BrN₃O
Molecular Weight	296.16 g/mol
Synonyms	5-Bromo-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one; 5-Bromo-1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 5-bromo-1,3-dihydro-1-(4-piperidinyl)-; 5-Bromo-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 58878-84-5; 5-Bromo-1-(4-piperidyl)-1H-benzimidazol-2(3H)-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(Piperidin-4-Yl)-1H-Benzo[D]Imidazol-2(3H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.