Description

3,4:5,6-Di-o-Isopropylidene-D-Glucitol is a high-purity, protected sugar alcohol derivative widely used as a key chiral building block and intermediate in organic synthesis. Its rigid, bicyclic structure provides a versatile scaffold for the stereoselective construction of complex molecules, making it invaluable for pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for producing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor for the synthesis of nucleoside analogs, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for the preparation of enantiomerically pure compounds in medicinal chemistry.
• Carbohydrate Chemistry: Used in the research and development of novel glycosidase inhibitors, glycomimetics, and complex oligosaccharides.
• Agrochemical Synthesis: Acts as a building block for creating chiral active ingredients in herbicides and fungicides.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Research: A valuable reagent in university and institutional labs for methodological development in organic synthesis.

Basic Information

Product Name	3,4:5,6-Di-o-Isopropylidene-D-Glucitol
CAS No.	58846-25-6
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	1,2:5,6-Di-O-isopropylidene-D-glucitol; D-Glucitol, 1,2:5,6-bis-O-(1-methylethylidene)-; Diacetone-D-sorbitol; Diacetone-D-glucitol; 1,2:5,6-Di-O-isopropylidene-D-sorbitol; Di-O-isopropylidene-D-sorbitol; Diacetone sorbitol; (3aR,5R,6S,6aR)-5-[(R)-1,2-Dihydroxyethyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol
EINECS	261-459-1

Quality Control

Our 3,4:5,6-Di-o-Isopropylidene-D-Glucitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and chiral purity analysis, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to specifications. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.