Description

3-(Bromomethyl)-1-Tosyl-1H-Indole is a versatile and high-value brominated indole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functionality, featuring a reactive bromomethyl group and a tosyl-protected indole nitrogen, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active indole alkaloids and potential drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Building block for creating novel fungicides, herbicides, and plant growth regulators with indole-based structures.
• Material Science Research: Used in the development of organic semiconductors, photochromic materials, and advanced polymers.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations for C-C and C-N bond formation.
• Nucleophilic Substitution Scaffold: The bromomethyl group is readily displaced by various nucleophiles (amines, thiols, alkoxides) to introduce diverse functional handles.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules due to its reactive halogen and aromatic structure.

Basic Information

Product Name	3-(Bromomethyl)-1-Tosyl-1H-Indole
CAS No.	58550-81-5
Molecular Formula	C17H16BrNO2S
Molecular Weight	378.28 g/mol
Synonyms	1H-Indole, 3-(bromomethyl)-1-[(4-methylphenyl)sulfonyl]-; 3-(Bromomethyl)-1-(p-toluenesulfonyl)indole; 1-Tosyl-3-(bromomethyl)indole; 3-Bromomethyl-1-tosylindole; N-Tosyl-3-(bromomethyl)indole; 3-Bromomethyl-1-(4-methylphenylsulfonyl)-1H-indole; 58550-81-5; 1-(4-Methylbenzenesulfonyl)-3-(bromomethyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 3-(Bromomethyl)-1-Tosyl-1H-Indole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure consistency and reliability for your synthetic workflows. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.