Description

Threo-Glycopyrronium Bromide is a high-purity, pharmaceutically relevant quaternary ammonium salt. This compound is a critical intermediate and active pharmaceutical ingredient (API) used in the synthesis of anticholinergic medications. It is essential for manufacturers in the pharmaceutical and fine chemical industries requiring a reliable source of a well-characterized muscarinic antagonist for research, development, and production.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in anticholinergic and antispasmodic drug formulations.
• Chemical Intermediate: Key building block in the multi-step synthesis of complex therapeutic agents targeting muscarinic receptors.
• Research & Development: Used in preclinical and clinical studies for developing new treatments for conditions like chronic obstructive pulmonary disease (COPD), excessive sweating (hyperhidrosis), and gastrointestinal disorders.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Formulation Development: Utilized in creating stable dosage forms such as tablets, injectables, and topical preparations.

Basic Information

Product Name	Threo-Glycopyrronium Bromide
CAS No.	58493-54-2
Molecular Formula	C19H28BrNO3
Molecular Weight	398.34 g/mol
Synonyms	Glycopyrronium Bromide (Threo-isomer); 3-[(2-Cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethylpyrrolidinium Bromide; Glycopyrrolate Bromide; Robinul; AHR-504; Cuvposa; Seebri (referring to formulations); (3RS)-3-[(2S)-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy]-1,1-dimethylpyrrolidinium Bromide
EINECS	261-280-7

Quality Control

Our Threo-Glycopyrronium Bromide is manufactured under strict quality systems. It is typically produced to meet pharmaceutical-grade standards, with specifications aligned with major pharmacopoeias such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Every batch undergoes comprehensive analytical testing including HPLC for assay and impurity profiling. A Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Optical Rotation	Specific range per grade (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.