Description

5-Chloro-4-Nitrothiophene-2-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride and nitro-substituted thiophene core. This compound matters for its critical role in synthesizing complex molecules, particularly in the development of advanced agrochemicals and pharmaceuticals, where it serves as a key building block. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries seeking to introduce specific sulfur-containing functionalities into their target compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the thiophene sulfonyl moiety contributes to biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, dyes, and liquid crystals due to its electron-withdrawing substituents.
• Chemical Biology Probes: Employed in the development of activity-based probes and other research tools that target sulfhydryl groups in proteins.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl systems.
• Sulfonamide Library Synthesis: The reactive sulfonyl chloride group is ideal for high-throughput parallel synthesis to create diverse sulfonamide libraries for screening.

Basic Information

Item	Details
Product Name	5-Chloro-4-Nitrothiophene-2-Sulfonyl Chloride
CAS No.	58457-24-2
Molecular Formula	C4HCl2NO4S2
Molecular Weight	276.14 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-chloro-4-nitro-; 5-Chloro-4-nitro-2-thiophenesulfonyl chloride; 5-Chloro-4-nitrothiophene-2-sulfonyl chloride; 4-Nitro-5-chlorothiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-chloro-4-nitro-; 5-Chloro-4-nitrothiophene-2-sulphonyl chloride; 58457-24-2; 5-Chloro-4-nitrothiophene-2-sulfonylchloride
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Nitrothiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and amines.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.