Description

5-Mercaptouridylic Acid is a modified nucleoside derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and precursor for the synthesis of oligonucleotides and other biologically active molecules. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in nucleic acid chemistry, drug discovery, and molecular biology applications.

Application

• Oligonucleotide Synthesis: A key monomeric component for the solid-phase synthesis of modified RNA and DNA strands, particularly those requiring thiol functionalization.
• Bioconjugation & Labeling: The thiol group enables site-specific conjugation with maleimides, gold nanoparticles, or other probes for creating diagnostic tools and targeted delivery systems.
• Pharmaceutical Intermediates: Serves as a vital precursor in the research and development of novel antiviral and anticancer therapeutics that target nucleic acid pathways.
• Biochemical Research: Used in enzymatic studies, structural biology, and as a substrate or inhibitor to investigate RNA metabolism and related cellular processes.
• Diagnostic Probe Development: Incorporated into probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays to enhance specificity or stability.
• Crosslinking Studies: Employed in studies of RNA-protein interactions and nucleic acid structure due to its reactive thiol moiety.

Basic Information

Product Name	5-Mercaptouridylic Acid
CAS No.	58380-75-9
Molecular Formula	C9H12N2O8S
Molecular Weight	308.27 g/mol
Synonyms	5-Mercapto-2'-deoxyuridine 5'-monophosphate; 5-Thiouridylic Acid; 5-SH-dUMP; 5-Mercapto-dUMP; 2'-Deoxy-5-mercaptouridine 5'-monophosphate; 5-Thio-2'-deoxyuridine 5'-phosphate; 5-Mercapto-2'-deoxyuridine monophosphate
EINECS	Contact for details

Quality Control

Our 5-Mercaptouridylic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.