Description

(Bromodifluoromethyl)Triphenylphosphonium Bromide is a high-value organophosphorus reagent, specifically a stabilized ylide precursor, widely used in synthetic organic chemistry. Its core value lies in enabling the efficient introduction of the bromodifluoromethyl group, a key moiety for modulating the physicochemical properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing difluoromethylated and gem-difluoroalkene scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Product Development: Used in the synthesis of novel herbicides, fungicides, and pesticides where the difluoromethyl group enhances biological activity and stability.
• Material Science Research: Employed in the creation of fluorinated organic compounds for electronic materials, liquid crystals, and polymers.
• Wittig and Related Olefination Reactions: Serves as a specialized Wittig reagent for the preparation of vinyl bromides and gem-difluoroolefins under mild conditions.
• Medicinal Chemistry & Drug Discovery: Facilitates late-stage functionalization and SAR (Structure-Activity Relationship) studies by introducing metabolically stable difluoromethyl groups.
• Academic & R&D Laboratories: A fundamental tool for methodology development in organofluorine chemistry and new reaction exploration.

Basic Information

Product Name	(Bromodifluoromethyl)Triphenylphosphonium Bromide
CAS No.	58201-66-4
Molecular Formula	C20H15Br2F2P
Molecular Weight	496.11 g/mol
Synonyms	Bromodifluoromethyltriphenylphosphonium Bromide; Triphenyl(bromodifluoromethyl)phosphonium Bromide; (Bromodifluoromethyl)triphenyl-λ5-phosphanebromide; Bromodifluoromethyl(triphenyl)phosphonium Bromide; Phosphonium, (bromodifluoromethyl)triphenyl-, bromide; Bromo(difluoro)methylidenetriphenylphosphorane hydrobromide adduct
EINECS	Contact for details

Quality Control

Our (Bromodifluoromethyl)Triphenylphosphonium Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 31P) and HPLC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material upon request, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) and opened only in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
1H NMR	Conforms to structure
19F NMR	Conforms to structure
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.