Description

Chloroquine, D- CAS NO 58175-86-3 is the dextrorotatory enantiomer of the well-known antimalarial compound chloroquine. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development, particularly for investigating structure-activity relationships and chiral pharmacology. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic agents and studying metabolic pathways.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development and quality control in drug manufacturing.
• Metabolic and Pharmacokinetic Studies: Used in research to understand the distinct biological activity, absorption, and distribution of the D-enantiomer compared to the racemic mixture or the L-form.
• Chiral Synthesis Intermediate: Acts as a key building block in the asymmetric synthesis of more complex, enantiomerically pure pharmaceutical compounds.
• Biological Mechanism Research: Employed in vitro and in vivo studies to elucidate the specific interactions and mechanisms of action attributable to this enantiomer.
• Impurity Profiling: Essential for identifying and quantifying enantiomeric impurities in batches of the active pharmaceutical ingredient (API) chloroquine phosphate or hydrochloride.

Basic Information

Product Name	Chloroquine, D-
CAS No.	58175-86-3
Molecular Formula	C₁₈H₂₆ClN₃
Molecular Weight	319.87 g/mol
Synonyms	(+)-Chloroquine; D-(+)-Chloroquine; Dextro-Chloroquine; (R)-Chloroquine; (R)-N'-(7-Chloroquinolin-4-yl)-N,N-diethylpentane-1,4-diamine; (+)-N'-(7-Chloro-4-quinolyl)-N,N-diethyl-1,4-pentanediamine; UNII-8864008S3P
EINECS	Contact for details

Quality Control

Our Chloroquine, D- is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific pharmacopeial or internal standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.