Description

Sitamaquine,N,n-Diethyl-N'-(6-Methoxy-4-Methyl-Quinolin-8-Yl)-Hexane-1,6-Diamine is a synthetic 8-aminoquinoline derivative with a unique diamine side chain, representing a significant class of antimalarial research compounds. Its primary value lies in its potential as a lead candidate for the development of novel therapeutic agents targeting parasitic diseases. This high-purity chemical is essential for pharmaceutical R&D laboratories, medicinal chemistry programs, and academic institutions focused on infectious disease research and drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical studies for novel antimalarial drugs.
• Medicinal Chemistry: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize efficacy and reduce toxicity of 8-aminoquinoline analogs.
• Biochemical Assays: Employed in in vitro and in vivo screening assays to evaluate antiparasitic activity and mechanism of action.
• Reference Standard: Provides a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Academic Research: Supports fundamental research in parasitology and the study of drug resistance mechanisms in Plasmodium species.

Basic Information

Item	Details
Product Name	Sitamaquine,N,n-Diethyl-N'-(6-Methoxy-4-Methyl-Quinolin-8-Yl)-Hexane-1,6-Diamine
CAS No.	57695-04-2
Molecular Formula	C25H37N3O
Molecular Weight	395.58 g/mol
Synonyms	Sitamaquine; WR 6026; N,N-Diethyl-N'-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine; 1,6-Hexanediamine, N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-; 8-[(6-(Diethylamino)hexyl)amino]-6-methoxy-4-methylquinoline; WR-6026; Antimalarial Agent WR 6026
EINECS	Contact for details

Quality Control

Our Sitamaquine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR, MS), and control of specified impurities. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against predefined specifications. Quality standards are aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.