Description

D-n-Cyclobutylmethyl-3,14-Dihydroxymorphinan is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and study of novel opioid receptor ligands. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in central nervous system (CNS) drug discovery, analytical method development, and the production of controlled active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathways for potent opioid analgesics and antagonist development.
• Reference Standard: Used in analytical laboratories for method validation, quality control (QC), and regulatory compliance testing of related drug substances.
• Medicinal Chemistry Research: Fundamental scaffold for structure-activity relationship (SAR) studies targeting kappa, mu, and delta opioid receptors.
• Preclinical Development: Serves as a starting material or intermediate in the synthesis of compounds for pharmacological evaluation and toxicology studies.
• Controlled Substance Synthesis: Intermediate in the licensed, regulated production of specific scheduled pharmaceutical agents.
• Biochemical Tool Compound: Utilized in vitro and ex vivo to study opioid receptor binding, signaling pathways, and physiological effects.

Basic Information

Product Name	D-n-Cyclobutylmethyl-3,14-Dihydroxymorphinan
CAS No.	58115-67-6
Molecular Formula	C22H31NO3
Molecular Weight	357.49 g/mol
Synonyms	(-)-Cyclobutylmethyl-3,14-dihydroxymorphinan; D-Cyclobutylmethylnoroxymorphone; 17-Cyclobutylmethyl-4,5α-epoxy-3,14-dihydroxymorphinan; Noroxymorphone cyclobutylmethyl derivative; 3,14-Dihydroxy-17-cyclobutylmethylmorphinan; N-Cyclobutylmethylnoroxymorphone; Opioid morphinan derivative 58115-67-6
EINECS	Contact for details

Quality Control

Our D-n-Cyclobutylmethyl-3,14-Dihydroxymorphinan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) with batch-specific data are provided to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.