Description

Ergoline-8-Methanol, 10-Methoxy-1,6-Dimethyl-, 8-(5-Bromo-3-Pyridinecarboxylate), (8α)- is a complex ergoline derivative, a class of compounds known for their significant biological activity. This specific brominated pyridinecarboxylate ester is a crucial advanced pharmaceutical intermediate for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical development teams focused on central nervous system (CNS) targets and receptor modulation.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel ergot alkaloid derivatives and potential drug candidates.
• Neurological Research: Used in preclinical studies targeting serotonin (5-HT) and dopamine receptor systems.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacological profiles.
• Reference Standard: Employed as an analytical standard in quality control and method development for related compounds.
• Biochemical Tool Compound: Utilized in vitro to study receptor binding affinity and functional activity.

Basic Information

Product Name	Ergoline-8-Methanol, 10-Methoxy-1,6-Dimethyl-, 8-(5-Bromo-3-Pyridinecarboxylate), (8α)-
CAS No.	58001-19-7
Molecular Formula	C22H23BrN2O4
Molecular Weight	459.34 g/mol
Synonyms	(8α)-10-Methoxy-1,6-dimethylergoline-8-methanol 8-(5-bromo-3-pyridinecarboxylate); 8α-10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromonicotinate; 5-Bromonicotinic acid (8α)-10-methoxy-1,6-dimethylergoline-8-methyl ester; Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8α)-; 58001-19-7; 8-(5-Bromo-3-pyridinecarbonyl)-10-methoxy-1,6-dimethylergoline-8-methanol
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure consistency and traceability. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.