Description

Methyl (41R,12R,13As)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate is a complex, stereochemically defined heterocyclic compound of significant interest in advanced organic synthesis. This molecule serves as a critical chiral building block or advanced intermediate for the development of novel pharmacologically active agents. It is primarily required by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of complex alkaloid-like structures for therapeutic applications.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential drug candidates targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Alkaloid Synthesis: Serves as a core structural unit for the construction of complex polycyclic alkaloid analogs with biological activity.
• Asymmetric Synthesis: Employed in advanced catalytic and stoichiometric asymmetric transformations due to its defined stereocenters.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes to complex target molecules in late-stage R&D.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl (41R,12R,13As)-13A-Ethyl-12-Hydroxy-2,3,41,5,6,12,13,13A-Octahydro-1H-Indolo[3,2,1-De]Pyrido[3,2,1-Ij][1,5]Naphthyridine-12-Carboxylate
CAS No.	58000-63-8
Molecular Formula	C22H26N2O3
Molecular Weight	366.46 g/mol
Synonyms	Methyl 13a-ethyl-12-hydroxy-2,3,4a,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; (12R,13aR)-Methyl 13a-ethyl-12-hydroxy-1,2,3,4,4a,5,6,12,13,13a-decahydroindolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate; Yohimbane derivative intermediate; Pentacyclic indole alkaloid intermediate
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical characterization, including HPLC for purity, chiral analysis, and structural confirmation via NMR and MS, to ensure it meets stringent R&D specifications. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.