Description

1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acidethyl Ester Hydrochloride is a high-purity, pharmaceutically relevant intermediate in salt form, offering enhanced stability for synthesis and formulation. This compound is a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for its versatile synthetic utility.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds and potential drug candidates targeting neurological and cardiovascular diseases.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the isoquinoline scaffold for bioactive molecule design.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing nitrogen-containing heterocycles and exploring novel chemical spaces.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, quality control, and regulatory submissions in pharmaceutical manufacturing.
• Material Science Precursor: Investigated for the synthesis of specialized polymers, ligands for catalysis, and advanced organic materials.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acidethyl Ester Hydrochloride
CAS No.	57980-74-2
Molecular Formula	C₁₂H₁₆ClNO₂
Molecular Weight	241.71 g/mol
Synonyms	Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid ethyl ester HCl; 3-Carbethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; THIQ-3-COOEt·HCl; Ethyl 3-isoquinolinecarboxylate hydrochloride, tetrahydro-; A-77636 hydrochloride (research code); Tetrahydroisoquinoline-3-carboxylic acid ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acidethyl Ester Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.