Description

4-[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]-2-Cyano-3-Oxobutyric Acid Ethyl Ester is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research importance. This compound serves as a critical synthetic precursor in the production of advanced pharmaceutical actives, particularly for its role in developing potent anti-inflammatory agents. It is essential for R&D laboratories, process chemists, and manufacturers in the global pharmaceutical and fine chemical sectors seeking reliable, high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of indole-based non-steroidal anti-inflammatory drugs (NSAIDs).
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel therapeutic compounds targeting inflammation and pain.
• Biochemical Research: Serves as a reference standard and probe in pharmacological studies to understand COX enzyme inhibition mechanisms.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Process Chemistry & Scale-Up: Critical for optimizing synthetic routes and scaling production from laboratory to pilot and commercial manufacturing.

Basic Information

Product Name	4-[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]-2-Cyano-3-Oxobutyric Acid Ethyl Ester
CAS No.	57846-37-4
Molecular Formula	C24H21ClN2O5
Molecular Weight	452.89 g/mol
Synonyms	Ethyl 4-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-2-cyano-3-oxobutanoate; 2-Cyano-3-oxo-4-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]butyric Acid Ethyl Ester; Indomethacin Ethyl Ester Intermediate; 4-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-2-cyano-3-oxobutanoic Acid Ethyl Ester; 57846-37-4; Butanoic acid, 2-cyano-3-oxo-4-[1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]-2-Cyano-3-Oxobutyric Acid Ethyl Ester is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material meeting specific customer requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.