Description

2-Acetyl-4-[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]-3-Oxobutyric Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex indole-based structure. This compound matters for its critical role as a key building block in the synthesis of potent non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs). Pharmaceutical R&D and manufacturing teams need this high-quality intermediate to ensure the efficacy, purity, and regulatory compliance of their final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of specific NSAID (Non-Steroidal Anti-Inflammatory Drug) APIs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in multi-step organic synthesis for target drug molecules.
• Research & Development: Utilized in medicinal chemistry for the discovery and optimization of new therapeutic agents targeting inflammation and pain.
• Process Chemistry & Scale-Up: Employed in pilot plant and commercial-scale production under current Good Manufacturing Practices (cGMP).
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for proprietary drug synthesis.

Basic Information

Product Name	2-Acetyl-4-[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]-3-Oxobutyric Acid Ethyl Ester
CAS No.	57846-36-3
Molecular Formula	C25H24ClNO6
Molecular Weight	469.91 g/mol
Synonyms	Ethyl 2-Acetyl-4-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-3-oxobutanoate; 3-Oxobutyric Acid Ethyl Ester Derivative; Indomethacin Intermediate; 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetyl Ethyl Ester Ketone; 4-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-2-acetyl-3-oxobutanoic Acid Ethyl Ester; AIBN Intermediate (related); NSAID Synthetic Precursor
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality systems. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ validated analytical methods, including HPLC, GC, and NMR, to ensure the material meets exacting specifications for use in cGMP environments. Quality is managed in compliance with ISO 9001 standards, and custom synthesis can be performed under current Good Manufacturing Practice (cGMP) guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.