Description

[[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]Acetyl]Malonic Acid Dimethyl Ester is a sophisticated indole-based chemical intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, high-value active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research and development laboratories, pharmaceutical manufacturers, and fine chemical producers engaged in creating novel therapeutic agents and specialty compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other indole-derived therapeutic agents.
• Research & Development: Serves as a versatile building block in medicinal chemistry for the discovery and optimization of new drug candidates targeting various disease pathways.
• Fine Chemical Synthesis: Used in the production of complex, high-purity specialty chemicals for advanced material science and agrochemical applications.
• API Manufacturing: Employed in regulated Good Manufacturing Practice (GMP) environments for the commercial-scale production of active pharmaceutical ingredients.
• Biochemical Research: Utilized as a probe or substrate in enzymatic studies and biochemical assays due to its specific structural features.

Basic Information

Product Name	[[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]Acetyl]Malonic Acid Dimethyl Ester
CAS No.	57846-35-2
Molecular Formula	C25H24ClNO7
Molecular Weight	485.91 g/mol
Synonyms	Dimethyl [[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]malonate; (1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl)acetic Acid Malonic Acid Dimethyl Ester; 2-[[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]propanedioic Acid Dimethyl Ester; Indomethacin Intermediate; Indomethacin Precursor; Malonic Acid, [[1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]-, Dimethyl Ester; CAS 57846-35-2.
EINECS	Contact for details

Quality Control

Our [[1-(p-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-Yl]Acetyl]Malonic Acid Dimethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from HPLC, NMR, and mass spectrometry. Our quality systems are designed to support GMP compliance for use as a pharmaceutical intermediate, and we can tailor specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.