Description

L-Tyrosine-2,6-D2 CAS NO 57746-15-3 is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, specifically deuterated at the 2 and 6 positions of the aromatic ring. This compound is a critical tool for advanced research and development, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, proteomics, and metabolic pathway analysis.

Application

• Internal Standard for Quantitative Analysis: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS for the accurate quantification of L-Tyrosine in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolic Tracing Studies: Employed in tracer experiments to investigate tyrosine metabolism, protein synthesis rates, and the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and thyroid hormones.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-based drug candidates, improving data accuracy by correcting for ionization suppression/enhancement.
• Proteomics and Biomarker Research: Facilitates the relative and absolute quantification of proteins and peptides in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other mass spectrometry-based proteomic workflows.
• NMR Spectroscopy: Serves as a deuterated probe in nuclear magnetic resonance studies to elucidate molecular structure, dynamics, and interaction mechanisms without signal interference from protons.
• Nutritional and Clinical Research: Applied in studies examining amino acid turnover, inborn errors of metabolism (e.g., Tyrosinemia), and the impact of diet or disease states on protein metabolism.

Basic Information

Product Name	L-Tyrosine-2,6-D2
CAS No.	57746-15-3
Molecular Formula	C9H9D2NO3
Molecular Weight	183.20 g/mol
Synonyms	(2S)-2-Amino-3-(2,6-dideuterio-4-hydroxyphenyl)propanoic acid; L-Tyrosine-d2 (2,6); Tyrosine-2,6-d2; (S)-Tyrosine-2,6-d2; 4-Hydroxy-DL-phenylalanine-2,6-d2; 3-(4-Hydroxyphenyl)-2-aminopropionic acid-2,6-d2; H-DL-Tyr(2,6-d2)-OH; Y-2,6-d2
EINECS	Contact for details

Quality Control

Our L-Tyrosine-2,6-D2 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your research. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.