Description

Ethyl 3-(Diethoxyphosphoryl)-4-oxopentanoate is a high-value organophosphorus intermediate with a versatile β-ketoester and phosphonate functional group. This compound is critical for the synthesis of complex molecules, offering a key building block for constructing carbon-phosphorus bonds and facilitating Horner-Wadsworth-Emmons (HWE) olefination reactions. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for the production of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring phosphorus-containing scaffolds or α,β-unsaturated carbonyl moieties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, insecticides, and plant growth regulators that utilize phosphonate chemistry.
• Specialty Chemical Building Block: Employed in organic synthesis for constructing complex molecules via Horner-Wadsworth-Emmons (HWE) olefination, a pivotal reaction for forming carbon-carbon double bonds.
• Ligand and Catalyst Development: Serves as a precursor for the development of novel organophosphorus ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Investigated for the preparation of functional polymers and advanced materials with specific thermal or chemical properties.
• Academic and Industrial R&D: A valuable reagent for methodological development and exploratory chemistry in both university laboratories and corporate R&D centers.

Basic Information

Product Name	Ethyl 3-(Diethoxyphosphoryl)-4-oxopentanoate
CAS No.	57648-56-3
Molecular Formula	C11H21O6P
Molecular Weight	280.26 g/mol
Synonyms	Ethyl 3-(diethoxyphosphoryl)-4-oxopentanoate; Diethyl (3-ethoxycarbonyl-3-oxopropyl)phosphonate; Ethyl 4-oxo-3-(phosphono)pentanoate diethyl ester; 3-(Diethoxyphosphoryl)-4-oxopentanoic acid ethyl ester; Acetylacetic acid ethyl ester diethyl phosphonate; (Carbethoxymethyl)acetylphosphonic acid diethyl ester; Diethyl (1-ethoxycarbonyl-2-oxopropyl)phosphonate; Diethyl [(ethoxycarbonyl)acetyl]methylphosphonate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(Diethoxyphosphoryl)-4-oxopentanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.