Description

1H-Indazole, 5-Chloro-3-(Trifluoromethyl)- is a high-purity, multi-functional heterocyclic building block of significant commercial interest. This compound is valued for its unique molecular scaffold, which combines a halogenated indazole core with a trifluoromethyl group, offering distinct electronic and steric properties for advanced synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, anti-cancer agents, and central nervous system (CNS) therapeutics.
• Agrochemical Research: Serves as a crucial building block for designing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the indazole moiety.
• Material Science Precursor: Used in the synthesis of specialized organic ligands, dyes, and photoactive materials for electronic and optoelectronic applications.
• Chemical Biology Probe: Employed in the development of molecular probes and biochemical tools for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	1H-Indazole, 5-Chloro-3-(Trifluoromethyl)-
CAS No.	57631-13-7
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)-1H-indazole; 5-Chloro-3-(trifluoromethyl)indazole; 3-(Trifluoromethyl)-5-chloro-1H-indazole; 5-Chloro-3-trifluoromethylindazole; 57631-13-7; 5-Chloro-3-trifluoromethyl-1H-indazole; 1H-Indazole, 5-chloro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 5-Chloro-3-(Trifluoromethyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are supplied with every shipment, detailing specifications for identity, purity, and related substances. Our quality commitment supports applications from research to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.