Description

Calcium Bis[(S)-2-Hydroxy-3-Methylbutyrate] is a high-purity, organically bound calcium salt of the (S)-enantiomer of 2-hydroxy-3-methylbutyric acid. This compound matters for its superior bioavailability and targeted functionality as a nutritional and pharmaceutical-grade calcium source, offering advantages over inorganic salts. It is primarily needed by manufacturers in the nutraceutical, pharmaceutical, and high-end animal feed industries seeking advanced mineral delivery systems.

Application

• Dietary Supplements & Nutraceuticals: As a highly bioavailable source of calcium in capsules, tablets, and powdered formulations.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) requiring chiral, organically complexed calcium.
• Sports & Clinical Nutrition: Incorporated into specialized medical foods and performance nutrition products for bone and muscle support.
• Premier Animal Nutrition: A key ingredient in high-value aquaculture, poultry, and swine feed for improved skeletal development and mineral utilization.
• Food Fortification: For the enrichment of functional foods and beverages where a neutral flavor and high solubility are beneficial.
• Cosmetic & Personal Care: Potential use in skincare formulations for its mineral content and skin-conditioning properties.

Basic Information

Product Name	Calcium Bis[(S)-2-Hydroxy-3-Methylbutyrate]
CAS No.	57618-22-1
Molecular Formula	C10H18CaO6
Molecular Weight	274.33 g/mol
Synonyms	Calcium (S)-2-Hydroxy-3-methylbutyrate; Calcium HMB (S-form); (S)-Calcium β-Hydroxy β-Methylbutyrate; Calcium (S)-HMB; Calcium (S)-2-Hydroxy-3-methylbutanoate; (S)-HMB Calcium Salt; L-Leucic Acid Calcium Salt; Calcium bis((2S)-2-hydroxy-3-methylbutanoate)
EINECS	Contact for details

Quality Control

Our Calcium Bis[(S)-2-Hydroxy-3-Methylbutyrate] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for nutritional and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in its original, sealed packaging until use to prevent degradation and caking.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S)-isomer
Calcium Content (Titration)	14.0% - 15.5%
Loss on Drying	≤ 2.0%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Microbiological Analysis	Meets standard pharmaceutical limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.