Description

(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol is a high-purity chiral diol building block with significant utility in asymmetric synthesis. Its rigid, fused-ring structure and defined stereochemistry make it a valuable precursor for the development of complex pharmaceutical intermediates and fine chemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific stereocenters into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Catalyst Ligand Precursor: Used to develop novel chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Fine Chemical Synthesis: Building block for advanced materials, liquid crystals, and performance chemicals requiring specific stereochemistry.
• Agrochemical Research: Intermediate in the development of chiral pesticides and herbicides where biological activity is stereospecific.
• Academic & Process Chemistry: Valuable reagent for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	(1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol
CAS No.	57496-61-4
Molecular Formula	C10H12O2
Molecular Weight	164.20 g/mol
Synonyms	(1R,2R)-1,2,3,4-Tetrahydro-1,2-naphthalenediol; (1R,2R)-1,2-Dihydroxy-1,2,3,4-tetrahydronaphthalene; trans-(1R,2R)-1,2,3,4-Tetrahydro-1,2-naphthalenediol; (1R,2R)-THN-diol; (1R,2R)-Tetralin-1,2-diol; (1R,2R)-1,2-Dihydroxytetralin; (1R,2R)-1,2,3,4-Tetrahydroxy-1,2-naphthalenediol (incorrect but common search variant); (1R,2R)-trans-Tetrahydro-naphthalene-1,2-diol
EINECS	Contact for details

Quality Control

Our (1R,2R)-trans-1,2,3,4-Tetrahydro-1,2-Naphthalenediol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full specification data are provided to guarantee traceability, consistency, and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.