Description

tert-Butyl 3-Formyl-1H-Indole-1-Carboxylate is a high-value, protected indole derivative that serves as a versatile and critical synthetic intermediate in advanced organic chemistry. Its core value lies in the strategic positioning of both a formyl group and a Boc-protected nitrogen, enabling precise and sequential functionalization for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to build intricate heterocyclic scaffolds central to active ingredient development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of indole-based drug candidates, including kinase inhibitors, serotonin receptor modulators, and anti-cancer agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides that incorporate functionalized indole motifs.
• Material Science Research: Serves as a precursor for organic electronic materials and functional dyes, leveraging the indole core's electronic properties.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis, particularly in palladium-catalyzed cross-coupling and nucleophilic addition reactions.
• Peptidomimetics & Bioconjugation: The aldehyde functionality allows for use in linker chemistry and the creation of indole-containing peptide analogs.

Basic Information

Product Name	tert-Butyl 3-Formyl-1H-Indole-1-Carboxylate
CAS No.	57476-50-3
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	1-Boc-3-formylindole; 3-Formyl-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 3-formylindole-1-carboxylate; 1-(tert-Butoxycarbonyl)-1H-indole-3-carboxaldehyde; 1H-Indole-1-carboxylic acid, 3-formyl-, 1,1-dimethylethyl ester; Boc-3-formylindole; 3-Formylindole-1-Boc
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 3-Formyl-1H-Indole-1-Carboxylate is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our standard material typically meets a purity specification of ≥97% (by HPLC), suitable for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.