Description

Benzeneacetic Acid, α-[[(Trimethylsilyl)Oxy]Methyl]-, Methyl Ester is a specialized organosilicon-protected intermediate of significant value in synthetic organic chemistry. This compound is crucial for its role as a protected synthon, enabling complex multi-step synthesis under controlled conditions where sensitive functional groups must be preserved. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glycine derivative or related amino acid synthon in solid-phase and solution-phase peptide chemistry.
• Organic Synthesis Reagent: Serves as a versatile reagent for introducing protected carboxylate and silyl ether functionalities in complex molecule construction.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodological development and the synthesis of novel organic compounds.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, including flavors, fragrances, and advanced polymer precursors.
• Protecting Group Chemistry: Utilized in reactions where temporary protection of carboxylic acid and alcohol groups is required.

Basic Information

Product Name	Benzeneacetic Acid, α-[[(Trimethylsilyl)Oxy]Methyl]-, Methyl Ester
CAS No.	57397-46-3
Molecular Formula	C13H20O3Si
Molecular Weight	252.38 g/mol
Synonyms	Methyl 2-[(Trimethylsilyloxy)methyl]-2-phenylacetate; Methyl (Trimethylsilyloxymethyl)phenylacetate; 2-Phenyl-2-[(trimethylsilyl)oxy]methyl Methyl Acetate; (Trimethylsilyloxymethyl)phenylacetic Acid Methyl Ester; α-[(Trimethylsilyloxy)methyl]benzeneacetic Acid Methyl Ester; Glycine, N-(phenylmethyl)-, methyl ester, N-(trimethylsilyl)- derivative; TMS-protected phenylglycine methyl ester
EINECS	Contact for details

Quality Control

Our Benzeneacetic Acid, α-[[(Trimethylsilyl)Oxy]Methyl]-, Methyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.