Description

1-Hydroxy-7-Azabenzotriazole (HOAt) is a highly effective peptide coupling additive and a superior alternative to 1-Hydroxybenzotriazole (HOBt). This compound is critical for suppressing racemization and enhancing coupling efficiency in solid-phase peptide synthesis (SPPS) and solution-phase chemistry. It is an essential reagent for pharmaceutical R&D, biotechnology, and fine chemical synthesis where high-purity, high-yield peptide bond formation is required.

Application

• Primary additive in peptide coupling reactions to minimize racemization.
• Critical reagent in solid-phase peptide synthesis (SPPS) for producing complex peptides and proteins.
• Used in solution-phase synthesis of peptide fragments and biomolecules.
• Facilitates the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Employed in the preparation of peptidomimetics and other bioactive compounds.
• Acts as a catalyst in amide and ester bond formation in organic synthesis.
• Used in research laboratories for developing novel synthetic methodologies.
• Applied in the production of specialty chemicals and fine chemical intermediates.

Basic Information

Product Name	1-Hydroxy-7-Azabenzotriazole
CAS No.	57115-46-5
Molecular Formula	C5H4N4O
Molecular Weight	136.11 g/mol
Synonyms	HOAt; 1-Hydroxy-1H-1,2,3-triazolo[4,5-b]pyridine; 7-Aza-1-hydroxybenzotriazole; 1-Hydroxy-7-azabenzotriazole; 1H-1,2,3-Triazolo[4,5-b]pyridin-1-ol; Azabenzotriazol-1-ol; Coupling Additive HOAt
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-7-Azabenzotriazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.