Description

(R)-(-)-3-Chloro-1,2-Propanediol is a chiral chlorohydrin building block of significant importance in fine chemical synthesis. This optically active compound serves as a key intermediate for the production of enantiomerically pure pharmaceuticals, agrochemicals, and specialty materials. It is essential for research and manufacturing processes in the pharmaceutical, biotechnology, and advanced chemical sectors where stereochemical control is critical.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in β-blocker and other cardiovascular drug classes.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators where the specific (R)-enantiomer imparts desired biological activity.
• Chemical Research & Development: Serves as a versatile starting material or reagent in asymmetric synthesis and methodology development within academic and industrial R&D laboratories.
• Specialty Polymer & Resin Modifier: Employed to introduce chiral centers or reactive chlorohydrin functionalities into polymers, resins, and advanced material precursors.
• Bioconjugate Chemistry: Acts as a linker or functionalization agent in the synthesis of chiral probes, diagnostic agents, and bioconjugates.

Basic Information

Product Name	(R)-(-)-3-Chloro-1,2-Propanediol
CAS No.	57090-45-6
Molecular Formula	C3H7ClO2
Molecular Weight	110.54 g/mol
Synonyms	(R)-3-Chloro-1,2-propanediol; (R)-3-Chloropropane-1,2-diol; (R)-α-Chlorohydrin; (R)-3-MCPD; (R)-(-)-3-Chloropropylene glycol; (R)-3-Chloro-1,2-dihydroxypropane; (R)-Glycidol hydrochloride (related); (R)-1-Chloro-2,3-dihydroxypropane
EINECS	Contact for details

Quality Control

Our (R)-(-)-3-Chloro-1,2-Propanediol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We employ advanced analytical techniques, including chiral HPLC and NMR, to verify identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect quality and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	-15° to -18° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.