Description

11-Maleimidoundecanoic Acid Dihydrate is a heterobifunctional crosslinking agent featuring a maleimide group and a carboxylic acid group separated by a long alkyl chain. This compound is essential for creating stable, site-specific conjugates between thiol-containing molecules and amine-containing molecules under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing antibody-drug conjugates (ADCs), protein labeling, and advanced material science applications.

Application

• Bioconjugation & ADC Development: A key reagent for the site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues, forming stable thioether bonds.
• Protein & Peptide Modification: Used to functionalize proteins, peptides, and enzymes with various probes, tags, or surfaces through amine coupling of the carboxylic acid group.
• Surface Immobilization: Facilitates the covalent attachment of biomolecules to amine-functionalized surfaces, nanoparticles, or polymers for biosensor and diagnostic assay development.
• Polymer & Material Science: Serves as a building block for synthesizing functionalized polymers, hydrogels, and smart materials with tailored biological activity.
• Diagnostic Reagent Synthesis: Employed in the production of labeled antibodies, antigens, and other reagents used in immunoassays and histochemistry.

Basic Information

Product Name	11-Maleimidoundecanoic Acid Dihydrate
CAS No.	57079-02-4
Molecular Formula	C15H23NO5 · 2H2O
Molecular Weight	315.35 g/mol (Anhydrous basis)
Synonyms	11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic Acid Dihydrate; N-(10-Carboxydecyl)maleimide Dihydrate; Maleimidoundecanoic Acid Dihydrate; 11-Maleimidoundecanoic Acid; BMPS Long Chain; SM(PEG)11 Precursor; 1H-Pyrrole-1-undecanoic acid, 2,5-dihydro-2,5-dioxo-, dihydrate
EINECS	Contact for details

Quality Control

Our 11-Maleimidoundecanoic Acid Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and loss on drying. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant for long-term stability. The product is light-sensitive (store away from light) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	9.0 - 12.0% (Theoretical for dihydrate: ~10.3%)
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO; Slightly soluble in organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.