Description

1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity, pharmaceutically relevant building block and synthetic intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of complex bioactive molecules. It is primarily sought by fine chemical manufacturers, pharmaceutical R&D laboratories, and academic institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various therapeutic agents, including potential central nervous system (CNS) drugs and enzyme inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and lead optimization.
• Organic Synthesis Building Block: Used in the preparation of more complex heterocyclic compounds and chiral auxiliaries due to its fused ring structure.
• Biochemical Research: Employed in the study of biological pathways and as a reference standard in analytical method development.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals and advanced materials requiring high-purity inputs.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	57060-88-5
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid methyl ester hydrochloride; 3-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; THIQ-3-COOMe·HCl; Methyl (1,2,3,4-tetrahydro-3-isoquinolinyl)carboxylate hydrochloride; 3-Methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.