Description

1,2-Distearoyl-D70-3-Sn-Glycerophosphatidylcholine is a high-purity, deuterated phospholipid, specifically a phosphatidylcholine with stearoyl fatty acid chains. This compound is critically important for advanced research and development, particularly in the fields of structural biology and biophysics, where it serves as a key component in creating stable, defined membrane models. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of diagnostic reagents requiring precise, isotopically labeled materials for NMR spectroscopy, mass spectrometry, and other sophisticated analytical techniques.

Application

• Biophysical Research: Essential for constructing defined lipid bilayers and vesicles (liposomes) for studying membrane protein structure, dynamics, and interactions using techniques like NMR and neutron scattering.
• Analytical Standard: Serves as a critical internal standard or reference material in quantitative lipidomics and metabolomics studies via mass spectrometry.
• Drug Delivery System Development: Used in the formulation and characterization of advanced liposomal drug delivery carriers to improve targeting and stability.
• Membrane Protein Crystallization: Employed to create the lipidic cubic phase or other membrane mimetics essential for crystallizing integral membrane proteins.
• Diagnostic Reagent Manufacturing: Incorporated into high-sensitivity diagnostic assays and kits where consistent, high-purity lipid components are required.
• Stable Isotope Labeling: The deuterium (D70) labeling makes it invaluable for tracing metabolic pathways and for use in Fourier-transform infrared (FTIR) spectroscopy studies.

Basic Information

Product Name	1,2-Distearoyl-D70-3-Sn-Glycerophosphatidylcholine
CAS No.	56952-01-3
Molecular Formula	C46D70H18NO8P
Molecular Weight	~862.1 g/mol (deuterated form)
Synonyms	DSPC-d70; 1,2-Distearoyl-sn-glycero-3-phosphocholine-d70; Deuterated DSPC; 1,2-Di-O-octadecanoyl-sn-glycero-3-phosphocholine (deuterated); 3-sn-Phosphatidylcholine, 1,2-distearoyl-d70-; PC(18:0-d35/18:0-d35); Lipoid S100-d70 (analogous trade name); Deuterated Phosphatidylcholine
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are produced and tested under strict quality management systems. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical purity, and lipid composition. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (as phosphatidylcholine)
Isotopic Purity (Deuteration)	≥ 98 atom % D
Loss on Drying	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.