Description

(S)-2-[(Trimethylsilyl)Amino]-4-[[[(Trimethylsilyl)Oxy]Methyl]Phosphinyl]Butanoic Acid Trimethylsilyl Ester is a sophisticated organosilicon-protected amino phosphinic acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the stereoselective introduction of phosphinyl and amino functionalities, which are pivotal for constructing complex bioactive molecules. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel enzyme inhibitors, peptide mimetics, and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel protease inhibitors, antiviral agents, and other pharmacologically active molecules.
• Peptidomimetics Development: Used to incorporate non-hydrolyzable phosphinic acid isosteres into peptide backbones, creating stable enzyme inhibitors.
• Agrochemical Research: Building block for creating chiral phosphonate-based herbicides, fungicides, and plant growth regulators.
• Ligand Synthesis: Precursor for chiral phosphine-phosphinite or phosphine-aminophosphine ligands used in asymmetric catalysis.
• Chemical Biology Probes: Employed in the design of activity-based probes and transition-state analogs for studying enzyme mechanisms.
• Material Science: Potential monomer or modifier for creating specialized silicon- and phosphorus-containing polymers.

Basic Information

Product Name	(S)-2-[(Trimethylsilyl)Amino]-4-[[[(Trimethylsilyl)Oxy]Methyl]Phosphinyl]Butanoic Acid Trimethylsilyl Ester
CAS No.	56772-22-6
Molecular Formula	C14H34NO4PSi3
Molecular Weight	395.64 g/mol
Synonyms	(S)-2-[(Trimethylsilyl)amino]-4-[[[(trimethylsilyl)oxy]methyl]phosphinyl]butanoic acid trimethylsilyl ester; (S)-2-(Trimethylsilylamino)-4-((trimethylsilyloxy)methylphosphinyl)butyric Acid Trimethylsilyl Ester; (S)-ATMP Trimethylsilyl Ester; Phosphinothricin Derivative TMS Ester; (S)-2-Amino-4-(hydroxymethylphosphinyl)butyric Acid Tris(trimethylsilyl) Derivative; L-ATMP Tris-TMS; Chiral Phosphinylbutanoate TMS Ester
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using techniques including NMR, HPLC, and chiral analysis to confirm identity, chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.