Description

D-(+)-Threo-2-Amino-1-(p-Methylsulphonylphenyl)Propane-1,3-Diol Hydrochloride is a high-purity chiral intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its primary value lies in its role as a key synthetic precursor for the production of enantiomerically pure pharmaceuticals, particularly in the development of selective adrenergic agents and other therapeutic compounds. This compound is essential for research institutions, pharmaceutical development laboratories, and manufacturers requiring a reliable source of a critical chiral building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A crucial chiral building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for adrenergic receptor-targeting drugs.
• Chemical Synthesis: Used as a versatile intermediate in asymmetric synthesis and medicinal chemistry research for creating novel molecular entities.
• Analytical Reference Standard: Serves as a high-purity reference material for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating receptor-ligand interactions and the pharmacological activity of chiral amines.
• Process Development: Utilized in the scale-up and optimization of synthetic routes for pharmaceutical manufacturing.

Basic Information

Product Name	D-(+)-Threo-2-Amino-1-(p-Methylsulphonylphenyl)Propane-1,3-Diol Hydrochloride
CAS No.	56724-21-1
Molecular Formula	C11H17NO4S • HCl
Molecular Weight	295.78 g/mol
Synonyms	(1R,2S)-2-Amino-1-(4-methylsulfonylphenyl)propane-1,3-diol hydrochloride; D-Threo-Methylphenidate Impurity; D-(+)-Threo-Methylphenidate Related Compound A; (2S)-2-Amino-1-(4-methylsulfonylphenyl)propane-1,3-diol hydrochloride (D-threo isomer); p-Methylsulphonylphenylpropanediolamine hydrochloride; Ritalinic Acid Derivative; 4-Methylsulfonylphenylpropanediolamine HCl
EINECS	Contact for details

Quality Control

Our D-(+)-Threo-2-Amino-1-(p-Methylsulphonylphenyl)Propane-1,3-Diol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.