Description

D-Mabuterol is a high-purity, enantiomerically pure form of the β-2 adrenergic agonist Mabuterol. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its targeted pharmacological activity. It serves as a critical chiral intermediate or reference standard for the synthesis and analytical control of novel therapeutic agents. Key industries requiring this compound include pharmaceutical R&D, contract manufacturing organizations (CMOs), and analytical laboratories focused on respiratory and metabolic disorders.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of Mabuterol-based drug substances and products in quality control laboratories.
• Chiral Intermediate: Serves as a key building block in the enantioselective synthesis of advanced active pharmaceutical ingredients (APIs) targeting β-2 adrenergic receptors.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the disposition and activity of Mabuterol stereoisomers.
• Analytical Method Development: Essential for developing and validating precise chromatographic methods (e.g., Chiral HPLC) to separate and quantify enantiomers.
• Preclinical Research: Utilized in biological assays and studies to investigate the specific pharmacological effects and safety profile of the D-enantiomer.

Basic Information

Product Name	D-Mabuterol
CAS No.	56707-25-6
Molecular Formula	C13H18ClF3N2O
Molecular Weight	310.74 g/mol
Synonyms	(R)-Mabuterol; D-(-)-Mabuterol; (R)-4-Amino-α-[[(1,1-dimethylethyl)amino]methyl]-3,5-dichloro-α-(trifluoromethyl)benzenemethanol; Mabuterol D-isomer; (R)-3,5-Dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-4-(trifluoromethyl)benzyl alcohol; Mabuterol Enantiomer
EINECS	Contact for details

Quality Control

Our D-Mabuterol CAS NO 56707-25-6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is supplied with every order, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (D-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.