Description

5-(Methylsulfinyl)-1-O,2-O,3-o-Tris(Trimethylsilyl)-5-Deoxy-D-Ribofuranose is a sophisticated, fully protected ribofuranose derivative featuring a methylsulfinyl group at the 5-position. This compound matters as a key chiral building block and advanced intermediate in synthetic organic chemistry, enabling the precise construction of complex nucleoside analogs and other bioactive molecules. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel therapeutic agents and specialty chemicals.

Application

• Nucleoside and Nucleotide Analog Synthesis: Serves as a critical protected intermediate for constructing modified ribose scaffolds in antiviral and anticancer drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting viral and metabolic diseases.
• Oligonucleotide Chemistry: Acts as a building block in the solid-phase synthesis of oligonucleotides and their analogs for diagnostic and therapeutic applications.
• Glycosylation Reactions: Functions as a glycosyl donor or acceptor precursor in the synthesis of complex carbohydrates and glycoconjugates.
• Fine Chemical Synthesis: Employed as a chiral synthon for the production of high-value specialty chemicals and catalysts.
• Agrochemical Research: Utilized in developing novel, biologically active compounds for crop protection.
• Academic and Institutional Research: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry.

Basic Information

Product Name	5-(Methylsulfinyl)-1-O,2-O,3-o-Tris(Trimethylsilyl)-5-Deoxy-D-Ribofuranose
CAS No.	56700-80-2
Molecular Formula	C15H36O5SSi3
Molecular Weight	412.78 g/mol
Synonyms	5-Deoxy-5-(methylsulfinyl)-1,2,3-O-tris(trimethylsilyl)-D-ribofuranose; 1,2,3-O-Tris(trimethylsilyl)-5-deoxy-5-(methylsulfinyl)-D-ribofuranose; 5-(Methylsulfinyl)-1,2,3-O-tris-O-(trimethylsilyl)-5-deoxy-D-ribofuranose; Protected 5-Deoxy-5-(methylsulfinyl)ribofuranose; TMS-protected ribofuranose sulfoxide; D-Ribofuranose, 5-deoxy-5-(methylsulfinyl)-, 1,2,3-tris(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Every batch of 5-(Methylsulfinyl)-1-O,2-O,3-o-Tris(Trimethylsilyl)-5-Deoxy-D-Ribofuranose is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.