Description

D-Alanine-2-D1 is a stable isotope-labeled derivative of the non-essential amino acid D-alanine, specifically deuterated at the 2-position. This compound is a critical tool in advanced research, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR spectroscopy. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and analytical laboratories focused on proteomics, metabolic pathway analysis, and the development of novel diagnostic agents.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of D-alanine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in isotope-labeling studies to investigate bacterial cell wall biosynthesis, alanine metabolism, and other biochemical pathways without signal interference from endogenous alanine.
• NMR Spectroscopy Studies: Employed as a probe in nuclear magnetic resonance (NMR) to elucidate molecular structure, dynamics, and interactions due to the distinct properties of the deuterium label.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for candidate drugs targeting bacterial infections or neurological pathways involving D-amino acids.
• Proteomics and Biomarker Discovery: Enables precise, high-throughput quantification in proteomic workflows for discovering disease-related biomarkers.
• Microbiological Research: Applied in studies of bacterial physiology, particularly concerning peptidoglycan synthesis in antibiotic-resistant strains.

Basic Information

Product Name	D-Alanine-2-D1
CAS No.	56595-54-1
Molecular Formula	C₃H₆DNO₂
Molecular Weight	90.10 g/mol
Synonyms	(2R)-2-Amino(2-²H)propanoic acid; D-Alanine-2-d; D-2-Aminopropionic acid-2-d; Deuterated D-alanine; (R)-Alanine-2-d; D-α-Alanine-2-d; Alanine-2-d1 (D-form); (R)-2-Aminopropanoic-2-d acid
EINECS	Contact for details

Quality Control

Our D-Alanine-2-D1 is manufactured under strict quality systems to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (deuterium enrichment), chemical purity (by HPLC), and specific optical rotation. We support research and compliance needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR)	≥ 98 atom % D
Optical Rotation	+13.5° to +15.5° (c=1 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.