Description

Di-tert-Butylchlorosilane is a highly reactive organosilicon compound primarily used as a versatile protecting group reagent in organic synthesis. Its sterically hindered tert-butyl groups provide exceptional selectivity and stability, making it a critical tool for the protection of alcohols, amines, and other sensitive functional groups. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is paramount.

Application

• Protecting Group Reagent: Selective protection of hydroxyl groups in complex multi-step organic syntheses, particularly for carbohydrate and nucleoside chemistry.
• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) requiring temporary protection of sensitive sites.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where selective functional group manipulation is required.
• Peptide Chemistry: Protection of serine, threonine, or tyrosine side chains during solid-phase peptide synthesis (SPPS).
• Material Science Precursor: Serves as a starting material for the synthesis of specialized silane coupling agents and silicone-based polymers.
• Research & Development: A valuable reagent in academic and industrial R&D labs for methodology development and novel compound library generation.

Basic Information

Product Name	Di-tert-Butylchlorosilane
CAS No.	56310-18-0
Molecular Formula	C8H19ClSi
Molecular Weight	178.77 g/mol
Synonyms	Chlorodi-tert-butylsilane; Di-tert-butylchlorosilane; Di-tert-butylsilyl chloride; (tert-Butyl)2Si(H)Cl; Di-tert-butylsilanoyl chloride; DTBS-Cl; Di-t-butylchlorosilane; Chlorodi-t-butylsilane
EINECS	Contact for details

Quality Control

Our Di-tert-Butylchlorosilane is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent hydrolysis. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (20°C)	~0.88 g/mL
Refractive Index (n20/D)	~1.450

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.