Description

3,6-Dioxa-8-Mercaptooctan-1-Ol CAS NO 56282-36-1 is a bifunctional organic compound featuring both a terminal thiol (mercapto) group and a terminal hydroxyl group, linked by a polyether chain. This unique structure makes it a valuable heterobifunctional linker for conjugation chemistry, enabling the creation of stable bonds between diverse materials. It is primarily utilized in advanced material science and life science research for surface modification, polymer synthesis, and bioconjugation. Industries requiring precise molecular assembly, such as pharmaceuticals, diagnostics, and specialty polymers, rely on this high-purity intermediate.

Application

• Bioconjugation and Protein Modification: Acts as a heterobifunctional crosslinker for attaching peptides, proteins, or other biomolecules to surfaces, nanoparticles, or other polymers via thiol and hydroxyl reactivity.
• Surface Functionalization: Used to create self-assembled monolayers (SAMs) on gold or other metal surfaces for biosensors, diagnostic devices, and anti-fouling coatings.
• Polymer Synthesis and Modification: Serves as a chain transfer agent (CTA) in reversible addition-fragmentation chain-transfer (RAFT) polymerization or as a monomer/modifier for introducing thiol groups into polymer backbones.
• Nanoparticle Capping and Stabilization: Provides a stabilizing layer on quantum dots, gold nanoparticles, or other nanomaterials, imparting water solubility and further functionalization sites.
• Hydrogel Formation: Participates in the formation of crosslinked hydrogel networks through thiol-ene or thiol-acrylate click chemistry reactions.
• Adhesive and Sealant Formulations: Functions as an adhesion promoter or a reactive intermediate in the synthesis of specialty polyurethane or polysulfide-based adhesives and sealants.

Basic Information

Product Name	3,6-Dioxa-8-Mercaptooctan-1-Ol
CAS No.	56282-36-1
Molecular Formula	C6H14O3S
Molecular Weight	166.24 g/mol
Synonyms	8-Mercapto-3,6-dioxaoctan-1-ol; 2-[2-(2-Mercaptoethoxy)ethoxy]ethanol; Thiodiglycol Monohydroxyethyl Ether; 3,6-Dioxa-1,8-octanedithiol (common misnomer); Hydroxy-terminated PEG thiol; HO-PEG2-SH; α-Thio-ω-hydroxy-triethylene glycol; 2,2'-(Ethylenedioxy)diethanethiol (related isomer)
EINECS	Contact for details

Quality Control

Our 3,6-Dioxa-8-Mercaptooctan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support compliance with relevant standards for research use (ACS grade where applicable) and can tailor specifications for cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and prolong shelf life. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Disulfide Content (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.