Description

L-Phenyl-D5-Alanine CAS NO 56253-90-8 is a stable isotope-labeled analog of the essential amino acid L-phenylalanine, where five hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research and development, providing an essential internal standard for precise quantitative analysis. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications requiring exceptional accuracy and traceability.

Application

• Mass Spectrometry Internal Standard: Serves as a crucial reference compound for the accurate quantification of L-phenylalanine and related metabolites in complex biological matrices using LC-MS/MS and GC-MS.
• Metabolic Pathway Research: Used in tracer studies to investigate phenylalanine metabolism, protein synthesis rates, and disorders like phenylketonuria (PKU).
• Pharmaceutical Development: Employed in the research and quality control of peptide-based drugs and other pharmaceuticals where phenylalanine is a constituent.
• Clinical Diagnostics: Essential for developing and validating high-precision assays for amino acid analysis in plasma, urine, and other clinical samples.
• Nutritional Science Studies: Used in research on protein metabolism, amino acid absorption, and the formulation of specialized nutritional products.
• Isotope Labeling & Synthesis: Acts as a building block for the synthesis of more complex deuterium-labeled peptides, proteins, or organic molecules.

Basic Information

Product Name	L-Phenyl-D5-Alanine
CAS No.	56253-90-8
Molecular Formula	C9H6D5NO2
Molecular Weight	171.20 g/mol
Synonyms	(2S)-2-Amino-3-(2,3,4,5,6-pentadeuteriophenyl)propanoic acid; L-Phenylalanine-2,3,4,5,6-d5; L-Phenylalanine-d5; (S)-2-Amino-3-(pentadeuteriophenyl)propionic acid; Deuterated L-Phenylalanine; Phenylalanine-d5; L-Phe-d5; Stable Isotope Labeled L-Phenylalanine
EINECS	Contact for details

Quality Control

Our L-Phenyl-D5-Alanine is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity, and chiral purity. We adhere to relevant industry standards for fine chemicals and stable isotopes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	-33.0° to -37.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.