Description

1-O,3-O,5-o-Tris(Trimethylsilyl)-2-Deoxy-D-Erythro-Pentofuranose CAS NO 56227-33-9 is a key protected nucleoside intermediate, specifically a silyl-protected derivative of 2-deoxyribose. This compound is critical for providing a stable, reactive scaffold for the controlled synthesis of oligonucleotides and modified nucleosides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Oligonucleotide Synthesis: Serves as a crucial protected building block for the solid-phase and solution-phase synthesis of DNA and RNA analogs.
• Antisense & siRNA Therapeutics: Used in the research and production of therapeutic oligonucleotides targeting specific genes.
• Prodrug Development: Acts as an intermediate for creating prodrugs of nucleoside analogs to improve bioavailability and targeting.
• Chemical Biology Research: Employed in studies exploring nucleic acid structure, function, and enzyme interactions.
• Diagnostic Probe Synthesis: Utilized in the manufacture of labeled probes for genetic testing and molecular diagnostics.
• Pharmaceutical Intermediates: A high-purity intermediate for the GMP-compliant manufacturing of active pharmaceutical ingredients (APIs) in the nucleic acid space.

Basic Information

Product Name	1-O,3-O,5-o-Tris(Trimethylsilyl)-2-Deoxy-D-Erythro-Pentofuranose
CAS No.	56227-33-9
Molecular Formula	C14H34O4Si3
Molecular Weight	350.68 g/mol
Synonyms	2-Deoxy-D-ribose, 1,3,5-tris-O-(trimethylsilyl)-; 1,3,5-Tris-O-trimethylsilyl-2-deoxy-D-ribofuranose; 2-Deoxy-1,3,5-tris-O-(trimethylsilyl)-D-erythro-pentofuranose; TMS-protected 2-deoxyribose; Tris(trimethylsilyl) 2-deoxy-D-ribofuranoside; 2-Deoxy-D-erythro-pentofuranose, 1,3,5-tris-O-(trimethylsilyl)-; Protected 2'-deoxyribose intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and GC to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.