Description

5-Hydroxyindole-3-Acetic-2,2-D2 Acid is a deuterated analog of the major serotonin metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA). This compound is specifically designed for use as a high-purity internal standard in analytical chemistry, enabling precise quantification and method validation. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require accurate and reliable measurements of serotonin metabolism.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous 5-HIAA in complex biological matrices like plasma, urine, and cerebrospinal fluid.
• Neurochemical Research: Used in studies investigating serotonin synthesis, metabolism, and turnover rates in neurological and psychiatric disorders.
• Clinical Diagnostics: Supports the development and validation of diagnostic assays for carcinoid syndrome and other serotonin-related pathologies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug effects on the serotonergic system in preclinical and clinical research.
• Method Development and Validation: Serves as a stable, non-interfering reference standard to establish specificity, accuracy, and precision in analytical methods.
• Quality Control in Pharmaceutical Manufacturing: Used to monitor impurities and ensure batch consistency in the production of serotonergic drugs.

Basic Information

Product Name	5-Hydroxyindole-3-Acetic-2,2-D2 Acid
CAS No.	56209-31-5
Molecular Formula	C10H7D2NO3
Molecular Weight	195.19 g/mol
Synonyms	5-HIAA-2,2-D2; 5-Hydroxy-3-indolylacetic-2,2-D2 Acid; 2,2-Dideutero-5-hydroxyindole-3-acetic acid; Deuterated 5-HIAA; 5-Hydroxyindoleacetic Acid-d2; Serotonin Metabolite-d2; (2,2-Dideutero-5-hydroxy-1H-indol-3-yl)acetic acid
EINECS	Contact for details

Quality Control

Our 5-Hydroxyindole-3-Acetic-2,2-D2 Acid is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, deuterium incorporation, and purity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D2)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.