Description

1-(Trimethylsilyl)-1H-Indole-3-Propanoic Acid Methyl Ester is a versatile organosilicon-protected indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the trimethylsilyl (TMS) group, which acts as a protective moiety for the indole nitrogen, enabling selective functionalization and complex multi-step synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals where precise molecular architecture is required. CAS NO 56196-72-6.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex indole alkaloids, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Research: Used in developing novel plant growth regulators and pesticides that leverage the indole scaffold.
• Organic Synthesis: Serves as a protected precursor for the preparation of carboxylic acids, amides, and other functionalized indole derivatives via the propanoate side chain.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic materials with specific electronic properties.
• Academic & R&D: A valuable reagent for methodological studies in synthetic chemistry, particularly in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	1-(Trimethylsilyl)-1H-Indole-3-Propanoic Acid Methyl Ester
CAS No.	56196-72-6
Molecular Formula	C₁₅H₂₁NO₂Si
Molecular Weight	275.42 g/mol
Synonyms	Methyl 3-[1-(Trimethylsilyl)-1H-indol-3-yl]propanoate; 1H-Indole-3-propanoic acid, 1-(trimethylsilyl)-, methyl ester; Methyl 1-(trimethylsilyl)indole-3-propionate; 1-TMS-indole-3-propionic acid methyl ester; 1-Trimethylsilylindole-3-propanoic Acid Methyl Ester; 56196-72-6; 1-(Trimethylsilyl)indole-3-propionic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-1H-Indole-3-Propanoic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and industrial use. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.