Description

n-[[2-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-2-Oxoethyl]]-3-(2-Furyl)Propenamide is a specialized heterocyclic compound featuring a reactive N-hydroxysuccinimide (NHS) ester group and a furan-containing acrylamide moiety. This bifunctional structure makes it a valuable intermediate for bioconjugation and cross-linking applications, enabling the formation of stable amide bonds with primary amines under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for developing targeted drug delivery systems, diagnostic reagents, and functional polymers.

Application

• Bioconjugation Reagent: For coupling peptides, proteins, or antibodies to other biomolecules, nanoparticles, or solid surfaces via its NHS ester functionality.
• Cross-linking Agent: Used in the synthesis of hydrogels, polymer networks, and biomaterials where the furyl acrylamide group can participate in further reactions, such as Diels-Alder cycloadditions.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring targeted amine coupling.
• Diagnostic Probe Synthesis: Employed in the development of fluorescent probes, immunoassay components, and other diagnostic tools that require specific labeling.
• Surface Functionalization: For modifying the surface properties of materials (e.g., silicon, gold, polymers) to introduce specific chemical handles for subsequent biomolecule immobilization.
• Polymer Chemistry: Acts as a monomer or co-monomer in the preparation of specialty polymers with tailored reactivity and functionality.

Basic Information

Product Name	n-[[2-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-2-Oxoethyl]]-3-(2-Furyl)Propenamide
CAS No.	56186-55-1
Molecular Formula	C13H12N2O6
Molecular Weight	292.25 g/mol
Synonyms	3-(2-Furyl)-N-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-2-propenamide; N-[2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-3-(2-furanyl)-2-propenamide; 3-(2-Furyl)acrylamide-NHS ester; Furan acrylamide NHS ester; NHS ester of 3-(2-furyl)acrylic acid; N-(2-((2,5-Dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-3-(furan-2-yl)acrylamide; 1-[(2-[[3-(2-Furanyl)-1-oxo-2-propen-1-yl]amino]-2-oxoethyl]oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our n-[[2-[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]-2-Oxoethyl]]-3-(2-Furyl)Propenamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions, preferably with desiccant, to prevent hydrolysis of the reactive NHS ester group. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.