Description

[1-(Isothiocyanatoamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical synthetic intermediate. Its value lies in its dual functionality, offering a protected phosphonate group and a reactive isothiocyanate moiety, enabling precise chemical modifications in advanced synthesis. This high-purity building block is essential for researchers and manufacturers in pharmaceutical development, agrochemical discovery, and materials science who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting phosphate-mediated biological pathways.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and plant growth regulators with modified activity and stability profiles.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating sophisticated phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide and Protein Modification: The isothiocyanate group enables selective conjugation to amino groups, useful in bioconjugation and probe development.
• Surface Functionalization Agent: Employed to modify material surfaces (e.g., silica, metals) with specific phosphonate anchoring groups for enhanced properties.
• Chemical Biology Tool: Utilized in probe design to study enzyme activity, particularly phosphatases and kinases, due to its phosphonate mimicry.

Basic Information

Product Name	[1-(Isothiocyanatoamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-91-3
Molecular Formula	C12H29N2O3PSi2
Molecular Weight	336.51 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isothiocyanatoamino)pentyl]phosphonate; Phosphonic acid, P-[1-[(isothiocyanato)amino]pentyl]-, bis(trimethylsilyl) ester; 1-Amino-1-isothiocyanatopentylphosphonic Acid Bis(trimethylsilyl) Ester; (1-Isothiocyanatoaminopentyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Isothiocyanatoaminopentylphosphonate; 56051-91-3; [1-(Isothiocyanatoamino)amyl]phosphonic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our [1-(Isothiocyanatoamino)Pentyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to cGMP and ISO guidelines ensures a reliable supply of high-purity intermediates for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.