Description

[1-(Isothiocyanatoamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring both phosphonic acid ester and isothiocyanate functional groups, protected by trimethylsilyl groups. This unique bifunctional structure makes it a valuable advanced synthetic intermediate and key building block in sophisticated organic synthesis. It is primarily sought by R&D and production chemists in the pharmaceutical, agrochemical, and materials science sectors for constructing complex molecules and novel polymers.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition or requiring phosphorus-containing bioactive molecules.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides, insecticides, or plant growth regulators with modified activity profiles.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphonate-based ligands for metal catalysis and coordination chemistry.
• Polymer and Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers, coatings, or hybrid organic-inorganic materials.
• Chemical Biology Probes: Utilized to create isothiocyanate-functionalized probes for labeling proteins or other biomolecules due to its reactive isothiocyanate group.
• Peptide Mimetics and Modifications: Applied in peptide chemistry to introduce phosphonate or thiourea functionalities, altering stability and biological activity.

Basic Information

Product Name	[1-(Isothiocyanatoamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-89-9
Molecular Formula	C11H27N2O3PSi2
Molecular Weight	322.48 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isothiocyanatoamino)-2-methylpropyl]phosphonate; Phosphonic acid, [1-[(isothiocyanato)amino]-2-methylpropyl]-, bis(trimethylsilyl) ester; 1-(Isothiocyanatoamino)-2-methylpropylphosphonic acid bis(trimethylsilyl) ester; TMS-protected isothiocyanatoaminophosphonate; (Isothiocyanatoamino)isobutylphosphonic acid bis-TMS ester
EINECS	Contact for details

Quality Control

Our production of [1-(Isothiocyanatoamino)-2-Methylpropyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.