Description

[1-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical synthetic intermediate. This compound matters for its role in introducing functionalized phosphonate groups under mild conditions, enabling advanced material and pharmaceutical synthesis. It is primarily needed by research chemists and process development scientists in the agrochemical, pharmaceutical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate-based bioisosteres.
• Agrochemical Synthesis: Serves as a key building block for creating advanced herbicides, fungicides, and plant growth regulators with enhanced activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphonate ligands for metal catalysis and coordination chemistry.
• Surface Modification Agent: Used to functionalize metal oxides and other surfaces to alter wettability, corrosion resistance, or adhesion properties.
• Polymer and Material Science: Acts as a monomer or cross-linking agent in the development of flame-retardant polymers, dental materials, or specialty resins.
• Peptide and Protein Modification: Utilized for site-specific phosphorylation or thiocarbamoylation in bioconjugation strategies.

Basic Information

Product Name	[1-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-87-7
Molecular Formula	C10H25N2O3PSi2
Molecular Weight	308.46 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isothiocyanatoamino)propyl]phosphonate; Phosphonic acid, P-[1-[(isothiocyanato)amino]propyl]-, bis(trimethylsilyl) ester; 1-(Isothiocyanatoamino)propylphosphonic Acid Bis(trimethylsilyl) Ester; (Isothiocyanatoamino)propylphosphonate Bis-TMS Ester; TMS-Protected Isothiocyanatoaminopropylphosphonate; N-Isothiocyanato-1-aminopropylphosphonic Acid Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our [1-(Isothiocyanatoamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced material synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.