Description

[2-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical synthetic intermediate. Its value lies in the dual functionality of the phosphonic acid and isothiocyanate groups, enabling precise chemical modifications and the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, where it is used to introduce specific bioactive or coordinating motifs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring metal-chelating properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, plant growth regulators, and fungicides with phosphonate activity.
• Ligand and Chelator Precursor: Serves as a precursor for sophisticated ligands used in catalysis, metal extraction, and diagnostic imaging agents.
• Surface Modification Agent: Employed to functionalize metal oxides, silica, and other inorganic surfaces to alter wettability, adhesion, or biocompatibility.
• Polymer and Material Science: Incorporated into polymers to impart flame retardancy, improve thermal stability, or create ion-exchange resins.
• Peptide and Bioconjugation Chemistry: The isothiocyanate group allows for selective conjugation to amines, useful in creating labeled biomolecules or affinity probes.

Basic Information

Item	Details
Product Name	[2-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-81-1
Molecular Formula	C9H23N2O3PSi2
Molecular Weight	294.44 g/mol
Synonyms	Bis(trimethylsilyl) [2-(isothiocyanatoamino)ethyl]phosphonate; Phosphonic acid, [2-[(isothiocyanato)amino]ethyl]-, bis(trimethylsilyl) ester; 2-Aminoethylphosphonic acid bis(trimethylsilyl) ester isothiocyanate; ATEP-bis(TMS) ester isothiocyanate; (2-Isothiocyanatoethyl)phosphonic acid bis(trimethylsilyl) ester; N-Isothiocyanato-2-aminoethylphosphonic acid bis-TMS ester
EINECS	Contact for details

Quality Control

Our production of [2-(Isothiocyanatoamino)Ethyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Every lot is characterized by advanced analytical techniques including NMR, HPLC, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.