Description

[(Isothiocyanatoamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative that serves as a critical synthetic intermediate. This compound matters for its role in introducing functionalized phosphonate groups under mild conditions, enabling the synthesis of complex molecules with precise structural control. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate-based bioisosteres.
• Agrochemical Synthesis: Used in creating advanced herbicides, plant growth regulators, and fungicides with enhanced activity and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in metal catalysis and for surface functionalization in material science.
• Peptide and Protein Modification: Employed to introduce stable, functional handles onto biomolecules for conjugation, labeling, or immobilization studies.
• Polymer Chemistry: Monomer or cross-linking agent for producing specialty polymers with tailored thermal, mechanical, or surface properties.
• Chemical Biology Probes: Useful for developing activity-based probes to study enzyme function, particularly phosphatases and kinases.

Basic Information

Product Name	[(Isothiocyanatoamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	56051-78-6
Molecular Formula	C10H25N2O3PSi2
Molecular Weight	308.46 g/mol
Synonyms	Phosphonic acid, P-[(isothiocyanatoamino)methyl]-, bis(trimethylsilyl) ester; Bis(trimethylsilyl) [(isothiocyanatoamino)methyl]phosphonate; (Isothiocyanatoaminomethyl)phosphonic Acid Bis(trimethylsilyl) Ester; TMS-Protected Isothiocyanatoaminomethylphosphonate; N-(Isothiocyanato)-aminomethylphosphonic Acid Bis(TMS) Ester
EINECS	Contact for details

Quality Control

Our production of [(Isothiocyanatoamino)Methyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is fully characterized by NMR (1H, 13C, 31P), IR spectroscopy, and chromatographic methods (HPLC/GC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.