Description

1-(Trimethylsilyl)-9,10-Didehydro-N,n-Diethyl-6-Methylergoline-8β-Carboxamide is a high-purity, advanced pharmaceutical intermediate belonging to the ergoline alkaloid class. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel therapeutic agents targeting neurological and cardiovascular pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex ergoline-derived active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates targeting serotonin and dopamine receptor systems.
• Neurological Disorder Research: Serves as a precursor for compounds being studied for conditions such as migraines, Parkinson's disease, and hyperprolactinemia.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Development: Utilized in scaling up and optimizing synthetic routes for the commercial production of specialty chemicals.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying alkaloid chemistry and pharmacology.

Basic Information

Product Name	1-(Trimethylsilyl)-9,10-Didehydro-N,n-Diethyl-6-Methylergoline-8β-Carboxamide
CAS No.	55760-26-4
Molecular Formula	C25H37N3OSi
Molecular Weight	423.67 g/mol
Synonyms	1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide; 8β-[[(Diethylamino)carbonyl]methyl]-1-(trimethylsilyl)-6-methylergoline; 1-TMS-LSD derivative; Lysergamide, 1-(trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methyl-, (8β)-; 55760-26-4; 1-(Trimethylsilyl)-9,10-didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide; 1-TMS-9,10-Didehydro-N,N-diethyl-6-methylergoline-8β-carboxamide
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-9,10-Didehydro-N,n-Diethyl-6-Methylergoline-8β-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.