Description

n-Succinimidyl 3-Maleimidopropionate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive maleimide group. This dual functionality is critical for creating stable, site-specific conjugates between proteins, peptides, and other biomolecules, enabling advanced research and development. It is an essential tool for scientists and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay production.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cysteine residues.
• Protein-Protein/Peptide Conjugation: Creating stable, defined complexes for structural studies, vaccine development, and synthetic biology.
• Diagnostic Reagent Preparation: Immobilizing antibodies or antigens onto sensor surfaces, beads, or plates for ELISA, lateral flow assays, and biosensors.
• Fluorescent Probe & Dye Labeling: Conjugating fluorophores or other reporter molecules to proteins for imaging and detection applications.
• Polymer & Biomaterial Functionalization: Introducing reactive thiol groups onto polymers or nanoparticles for subsequent bioconjugation.
• Enzyme Immobilization: Covalent attachment of enzymes to solid supports for biocatalysis and industrial processes.

Basic Information

Item	Details
Product Name	n-Succinimidyl 3-Maleimidopropionate
CAS No.	55750-62-4
Molecular Formula	C11H10N2O6
Molecular Weight	266.21 g/mol
Synonyms	3-Maleimidopropionic Acid N-Hydroxysuccinimide Ester; SMP; Maleimidopropionic Acid Succinimidyl Ester; Succinimidyl 3-Maleimidopropionate; SM(PEG)n Reagent (core structure); NHS-PEG3-Maleimide (core structure); 3-Maleimidopropionic Acid NHS Ester; N-(3-Maleimidopropionyloxy)succinimide
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 3-Maleimidopropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive bioconjugation work. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in DMF, DMSO, acetonitrile
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.